2004 Breakout Sessions

D3 Breakout Session

Bioinformatics of High-Throughput Proteomics
Michael Ochs, PhD, James Lyons-Weiler, PhD, Milos Hauskrecht, PhD, Simon Lin, Harry Burke, MD, PhD, Jeffrey Morris, PhD, Zhen Zhang,PhD and Wei Zhu, PhD

The focus of this session will be to explore ways in which informaticians at distant sites can benefit by working together on a common bioinformatics analysis solution aimed at optimizing biomarker discovery in proteomic peptide time-of-flight (SELDI and MALDI-TOF) profiles. Panelists will include members of the caBIG initiative and the Early Research Detection Network. We will explore:

• Challenges in Accounting for Mass Drift in Proteomic Profiles
• Normalization and Baseline Subtraction
• Data Representation: What Should be Analyzed?
• Feature Selection Methods
• Construction and Validation of Classifiers
• Development standards for caProteo