Presented at the 1999 APIII Conference Return to 1999 Abstract Index
CANCER GENOME ANATOMY PROJECT: AN INTEGRATED WEB SITE FOR MOLECULAR PROFILING OF CANCER
National
Institutes of Health/National Cancer Institute
Bethesda, Maryland
Jennifer Swalwell
Jennifer Swalwell1, Michael Emmert-Buck1, John Pfeifer2, Calvin Johnson2, Art Wetzel3, Michael Becich4
1Pathogenetics
Unit, Laboratory of Pathology, National Cancer Institute
2Computational Bioscience and Engineering Laboratory, Center
for Information Technology, National Institutes of Health
3Pittsburgh Supercomputing Center, Carnegie Mellon University
4University of Pittsburgh Medical Center
As a part of the Cancer Genome Anatomy Project (CGAP), the Intramural Prostate Cancer Working Group at the National Cancer Institute (NCI) is preparing an integrated 'Molecular Profiling' site to be displayed on the World Wide Web. The site is designed for investigators and research groups employing newly developed high-throughput technologies to the study of human cancer and consists of three separate sections:
- Bedside
to Benchside: This introductory section describes
critical issues and challenges faced by investigators
studying tissue specimens. The goal is to stimulate thought
and highlight the questions which need to be addressed
in future molecular profiling research efforts.
- Protocols:
The protocol segment of the web site is a resource
of cutting-edge experimental methods and techniques being
utilized in molecular profiling efforts at the NCI. To
increase the educational value of the protocols site,
references, trouble-shooting suggestions, PubMed abstracts,
and relevant links are included.
- Prostate Cancer: This section provides research examples from the Prostate Cancer Working Group of the NCI. The highlight of this section, the 3D Prostate Model Demonstration, is the ongoing culmination of collaborative efforts between the National Institutes of Health, Pittsburgh Supercomputing Center, and the University of Pittsburgh Medical Center.
Integration of data resulting from high-throughput molecular analysis of tissue specimens is a daunting, but necessary task. The Molecular Profiling web site showcases one example of how such data may be organized and presented to the scientific community in a comprehensive manner. Ultimately, we envision the web site serving as a useful tool for molecular studies of human disease processes.
